%0 Journal Article
%T Arid1a controls tissue regeneration
%A Wu, Shuai
%A Zhang, Rugang
%A Bitler, Benjamin G.
%J Stem Cell Investigation
%D 2016
%B 2016
%9 
%! Arid1a controls tissue regeneration
%K 
%X Switch/Sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are crucial for regulating temporal and spatial gene expression during development (1). SWI/SNF   disrupts the DNA-histone interaction in an ATPase-dependent manner, alters the chromatin architecture and promotes a “poised” chromatin state (2,3). The poised state of chromatin makes it accessible for specific transcriptional regulators to facilitate tissue-specific gene expression profiles (4-6). SWI/SNF function is highly dependent on its subunit composition. Several SWI/SNF subunits, such as BAF155, BAF250a/b (ARID1A/B) and BRG1, are reported to affect self-renewal and differentiation in many tissues and embryonic stem (ES) cells (6-8). SWI/SNF complexes also increase transcriptional reprogramming efficiency during development (9). These studies implicate the SWI/SNF complexes are essential to embryonic development and tissue-specific differentiation.
%U https://sci.amegroups.org/article/view/11260
%V 3
%N 8
%P 
%@ 2313-0792