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Mesenchymal stem cell therapy for refractory scleroderma: a report of 2 cases

   
@article{SCI11699,
	author = {Terek Wehbe and Majid Abi Saab and Nassim Abi Chahine and Talar Margossian},
	title = {Mesenchymal stem cell therapy for refractory scleroderma: a report of 2 cases},
	journal = {Stem Cell Investigation},
	volume = {3},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {We treated 2 patients with progressive, refractory scleroderma with a combined immunotherapy approach using plasmapheresis followed by rituximab and then intravenous umbilical-cord-derived allogeneic mesenchymal stem cells (MSCs). Both patients improved subjectively and objectively for over a year. Upon recurrence of their symptoms, the patients were treated again with allogeneic MSCs alone with a very good response. The combination was well tolerated and effective suggesting a large scale study may be warranted in progressive, refractory Scleroderma.},
	issn = {2313-0792},	url = {https://sci.amegroups.org/article/view/11699}
}