@article{SCI12373,
author = {David W. Scoville and Anton M. Jetten},
title = {Studying pancreas development and diabetes using human pluripotent stem cells},
journal = {Stem Cell Investigation},
volume = {3},
number = {11},
year = {2016},
keywords = {},
abstract = {For over two decades now, studies into pancreatic development have relied largely on the mouse as a model organism. These studies have generated a wealth of information into the genetic regulatory networks involved in pancreas formation, identifying key transcription factors involved in early pancreatic differentiation, endocrine cell specification, and mature hormone-producing cell production [reviewed recently in (1)]. Many of these genes have been confirmed to play a role in β-cell development in humans as well, with some factors linked to monogenic forms of diabetes, while others through Genome-Wide Association Studies (GWAS) have been linked to increased risk of developing either type 1 or type 2 diabetes mellitus.},
issn = {2313-0792}, url = {https://sci.amegroups.org/article/view/12373}
}