@article{SCI15019,
author = {Sophie Servais and Muriel Hannon and Régis Peffault de Latour and Gérard Socie and Yves Beguin},
title = {Reconstitution of adaptive immunity after umbilical cord blood transplantation: impact on infectious complications},
journal = {Stem Cell Investigation},
volume = {4},
number = {5},
year = {2017},
keywords = {},
abstract = {In comparison with allogeneic stem cell transplantation (alloHSCT) with other stem cell sources, umbilical cord blood transplantation (UCBT) was traditionally associated with increased risk of infections, particularly during the first 3 months after transplantation. Longitudinal studies of immune monitoring reported peculiar patterns of T- and B-cell recovery in the peripheral blood of UCB recipients during the first months post-transplantation. Overall, current data suggest delayed reconstitution of naive and memory CD4+ and CD8+ T-cell pools after UCBT. This is particularly true for adult recipients and for patients who received in vivo T-cell depleting approaches before the transplantation. Such delayed T-cell recovery may increase susceptibility of UCB recipients for developing opportunistic infections and viral reactivations. Regarding B-cell recovery, UCBT was associated with accelerated B-lymphopoiesis. Recent studies also reported evidence for faster functional memory B-cell recovery in UCB recipients. In this article, we briefly review T- and B-cell reconstitution after alloHSCT, with emphasis on peculiarities observed after UCBT. We further put these data in lines with risks of infections after UCBT.},
issn = {2313-0792}, url = {https://sci.amegroups.org/article/view/15019}
}