@article{SCI22502,
author = {Prahlad Parajuli and Sandeep Mittal},
title = {Picture of glioma stem cells has become a Notch brighter},
journal = {Stem Cell Investigation},
volume = {5},
number = {0},
year = {2018},
keywords = {},
abstract = {Solid tumors often behave like an organ system, comprised of rapidly proliferating cancer cells and a variety of stromal components, including endothelial cells (ECs), fibroblasts, and immune cells. Similar to an organ system, all tumors, including malignant gliomas, also contain a small population of cancer stem cells (CSCs) with adult stem cell-like characteristics, namely, pluripotency and capacity for self-renewal. CSCs are quiescent and have low immunogenicity—features that help them evade destruction by chemotherapy and immunotherapy, respectively. Identification of novel molecular cues that regulate maintenance (self-renewal) of CSCs could help develop new therapeutic interventions for complete eradication of cancer and avoid recurrence.},
issn = {2313-0792}, url = {https://sci.amegroups.org/article/view/22502}
}