@article{SCI5719,
author = {Zhiyuan Wu and Chen Zhang and Xiaochao Ma and Ming Guan},
title = {Clinical relevance between CALR mutation and myeloproliferative neoplasms},
journal = {Stem Cell Investigation},
volume = {2},
number = {2},
year = {2015},
keywords = {},
abstract = {In late 2013, somatic mutations in calreticulin (CALR), mainly those involving insertions and deletions in exon 9, attracted the great attention of hematologists and researchers. These JAK2- and MPL- mutual exclusive mutations enjoy a favorable specificity and prevalence (20-30%) in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), suggesting promise for these mutations in disease management. Moreover, these genetic variations are now also considered as a group of independent risk factors for disease prognosis. In this mini-review, we will document the value of CALR mutations in disease diagnosis, prognosis, and therapeutic strategy selection, and we will discuss current advances in methods to detect these mutations.},
issn = {2313-0792}, url = {https://sci.amegroups.org/article/view/5719}
}