%0 Journal Article
%T Clinical relevance between CALR mutation and myeloproliferative neoplasms
%A Wu, Zhiyuan
%A Zhang, Chen
%A Ma, Xiaochao
%A Guan, Ming
%J Stem Cell Investigation
%D 2015
%B 2015
%9 
%! Clinical relevance between CALR mutation and myeloproliferative neoplasms
%K 
%X In late 2013, somatic mutations in calreticulin (CALR), mainly those involving insertions and deletions in exon 9, attracted the great attention of hematologists and researchers. These JAK2- and MPL- mutual exclusive mutations enjoy a favorable specificity and prevalence (20-30%) in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), suggesting promise for these mutations in disease management. Moreover, these genetic variations are now also considered as a group of independent risk factors for disease prognosis. In this mini-review, we will document the value of CALR mutations in disease diagnosis, prognosis, and therapeutic strategy selection, and we will discuss current advances in methods to detect these mutations.
%U https://sci.amegroups.org/article/view/5719
%V 2
%N 2
%P 
%@ 2313-0792