TY  - JOUR
AU  - Wu, Zhiyuan
AU  - Zhang, Chen
AU  - Ma, Xiaochao
AU  - Guan, Ming
PY  - 2015
TI  - Clinical relevance between CALR mutation and myeloproliferative neoplasms
JF  - Stem Cell Investigation; Vol 2, No 2 (February 2015): Stem Cell Investigation
Y2  - 2015
KW  - 
N2  - In late 2013, somatic mutations in calreticulin (CALR), mainly those involving insertions and deletions in exon 9, attracted the great attention of hematologists and researchers. These JAK2- and MPL- mutual exclusive mutations enjoy a favorable specificity and prevalence (20-30%) in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), suggesting promise for these mutations in disease management. Moreover, these genetic variations are now also considered as a group of independent risk factors for disease prognosis. In this mini-review, we will document the value of CALR mutations in disease diagnosis, prognosis, and therapeutic strategy selection, and we will discuss current advances in methods to detect these mutations.
UR  - https://sci.amegroups.org/article/view/5719