TY  - JOUR
AU  - Feng, Wenli
AU  - Wang, Lina
AU  - Zheng, Guoguang
PY  - 2015
TI  - Expression and function of P2 receptors in hematopoietic stem and progenitor cells
JF  - Stem Cell Investigation; Vol 2, No 7 (July 2015): Stem Cell Investigation
Y2  - 2015
KW  - 
N2  - Nucleotides have unambiguously emerged as a family of mediators of intercellular communication, which bind to a class of plasma membrane receptors, P2 receptors, to trigger intercellular signaling. P2 receptors can be further divided into P2X and P2Y subfamilies based on structure and function. Different hematopoietic cells express diverse spectrums of P2 receptors at different levels, including hematopoietic stem and progenitor cells (HSPCs). Extracellular adenosine triphosphate (ATP) exerts different effects on HSPCs, regulating cell proliferation, differentiation, migration, and chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species. The relationship between abnormal P2 receptor function and human diseases attracts more and more attention. This review summarizes the expression and function of P2 receptors in HSPCs and the relationship to hematopoietic diseases.
UR  - https://sci.amegroups.org/article/view/7033