Cohesin complex is a major player on the stage of leukemogenesis

Epigenetic changes are increasingly being recognized as part of the multistep tumorigenesis process in cancer. These changes, including DNA methylation, covalent histone modifications, and nucleosome remodeling, work together to regulate the functioning of the genome by altering the local structural dynamics of chromatin, primarily regulating its accessibility and compactness (1). Other chromatin organizing factors are believed to bind to noncoding regions and control long-range looping of DNA, which is important in regulating the spatial relationships between gene enhancers and promoters that control gene expression (2).