Histone chaperone in regulation of cellular metabolism dictating stem cell fate?

Cellular metabolism could regulate pluripotent states of embryonic stem cells (ESC) mediated by metabolites (1). These metabolites simultaneously could dictate the fate of pluripotent states through epigenetic modifications. Dynamicity in expression of three different metabolites namely, acetate, S-adenosylmethionine and O-linked β-N-acetylglucosamine facilitate the regulation of epigenetic landscape and thus influence the fate of ESCs and the pluripotent states (1). Human ESCs and mouse EpiESCs exist in a primed state of pluripotency in comparison to the naïve state of pluripotency in mouse ESCs (2). Colony morphologies, response to signaling pathways, contribution to generate chimera, epigenetic states and cellular metabolism distinctively divides these two states of pluripotency (2).