CRISPR-activation-based screen reveals neuronal fate promotion by polycomb repressive complex 2 during direct reprogramming

Conversion of one cell type to another by reprogramming offers valuable opportunities for disease modeling and regenerative medicine. In a much-anticipated scenario, tissues generated from reprogrammed cells will be used to replace degenerated or lost tissues in patients suffering from injury or diseases such as Alzheimer’s, which causes loss of functional nerve cells (neurons) in the brain.