Analysis of TCR repertoires for tracking and evaluating distinct T cell subsets

In this article published online of Stem cell Investigation 2015, Li et al. reviewed recent studies on T-cell receptor (TCR) repertoire diversity recovery in patients with leukemia and autoimmune disease who have received hematopoietic stem cell transplantation (HSCT). TCR repertoire diversity analysis has been a common method for characterizing immune reconstitution after HSCT and analyzing the oligoclonal expansion of T cells during virus infection, graft-versus-leukemia (GVL) effects, and graft-versus-host disease (GVHD) (1).