Inflammation-induced emergency megakaryopoiesis: inflammation paves the way for platelets

Classical model of hematopoietic system has assumed that self-renewing hematopoietic stem cells (HSCs) exist at the apex of developmental hierarchy and give rise to all of highly specialized hematopoietic cells. In this model, lineage commitment is accompanied by decreasing self-renewing capacity; self-renewing HSCs transit into transiently amplifying multipotent progenitors with full lymphomyeloid potentials, followed by lineage specification. Recent researches, however, have cast doubt on this simplified model and there still exists considerable uncertainty regarding hematopoietic development.